DICER1 Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. Belongs to the helicase family. Dicer subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; EC; Helicase; RNA processing; RNA-binding; Ribonuclease
Chromosomal Location of human Ortholog: 14q32.13
Cellular Component:  ARC complex; cytosol; dendrite; endoplasmic reticulum-Golgi intermediate compartment; extracellular exosome; growth cone; micro-ribonucleoprotein complex; RISC-loading complex
Molecular Function:  ATP binding; DNA binding; double-stranded RNA binding; endoribonuclease activity; helicase activity; metal ion binding; pre-miRNA binding; protein binding; protein domain specific binding; ribonuclease III activity; siRNA binding
Biological Process:  conversion of ds siRNA to ss siRNA; conversion of ds siRNA to ss siRNA involved in RNA interference; miRNA loading onto RISC involved in gene silencing by miRNA; miRNA metabolic process; negative regulation of gene expression; negative regulation of Schwann cell proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of tumor necrosis factor production; nerve development; neuron projection morphogenesis; NIK/NF-kappaB signaling; peripheral nervous system myelin formation; positive regulation of myelination; positive regulation of Schwann cell differentiation; pre-miRNA processing; production of miRNAs involved in gene silencing by miRNA; production of siRNA involved in RNA interference; RNA phosphodiester bond hydrolysis, endonucleolytic; siRNA loading onto RISC involved in RNA interference; targeting of mRNA for destruction involved in RNA interference; tube formation
Disease: Global Developmental Delay, Lung Cysts, Overgrowth, And Wilms Tumor; Goiter, Multinodular 1, With Or Without Sertoli-leydig Cell Tumors; Pleuropulmonary Blastoma; Rhabdomyosarcoma, Embryonal, 2
Reference #:  Q9UPY3 (UniProtKB)
Alt. Names/Synonyms: DCR1; DICER; dicer 1, double-stranded RNA-specific endoribonuclease; dicer 1, ribonuclease III; dicer 1, ribonuclease type III; DICER1; Dicer1, Dcr-1 homolog; Dicer1e; Endoribonuclease Dicer; GLOW; Helicase MOI; Helicase with RNase motif; helicase-moi; HERNA; K12H4.8-LIKE; KIAA0928; MNG1; RMSE2
Gene Symbols: DICER1
Molecular weight: 218,682 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein