|
SYNPO
Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity. Belongs to the synaptopodin family. Expressed in cerebral cortex. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Actin-binding; Cytoskeletal |
| Chromosomal Location of Human Ortholog: 5q33.1 |
|
Cellular Component:
actin cytoskeleton; bicellular tight junction; dendritic spine; glutamatergic synapse; perikaryon; postsynaptic density; postsynaptic membrane; Schaffer collateral - CA1 synapse
|
|
Molecular Function:
actin binding; protein binding
|
|
Biological Process:
modification of dendritic spine; positive regulation of postsynaptic cytosolic calcium concentration; postsynaptic modulation of chemical synaptic transmission; regulation of long-term neuronal synaptic plasticity; visual learning
|
|
Reference #:
Q8N3V7
(UniProtKB)
|
|
Alt. Names/Synonyms: KIAA1029; Synaptopodin; SYNPO
|
|
Gene Symbols: SYNPO
|
|
Molecular weight:
99,463 Da
|
|
Basal Isoelectric point:
8.92
Predict pI for various phosphorylation states
|
