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SLP-2
Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation. Belongs to the band 7/mec-2 family. Ubiquitously expressed at low levels. Expressed in lymphoid tissues (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Mitochondrial |
| Chromosomal Location of human Ortholog: 9p13.3 |
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Cellular Component:
actin cytoskeleton; immunological synapse; membrane raft; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion; plasma membrane
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Molecular Function:
cardiolipin binding; GTPase binding; protein binding; T cell receptor binding
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Biological Process:
CD4-positive, alpha-beta T cell activation; intracellular calcium ion homeostasis; lipid localization; mitochondrial protein processing; mitochondrion organization; positive regulation of interleukin-2 production; protein complex oligomerization; proton motive force-driven mitochondrial ATP synthesis; stress-induced mitochondrial fusion; T cell receptor signaling pathway
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Reference #:
Q9UJZ1
(UniProtKB)
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Alt. Names/Synonyms: EPB72-like 2; EPB72-like protein 2; HSPC108; Paraprotein target 7; Paratarg-7; SLP-2; SLP2; STML2; stomatin (EPB72)-like 2; stomatin like 2; stomatin-like 2; Stomatin-like protein 2; Stomatin-like protein 2, mitochondrial; STOML2
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Gene Symbols: STOML2
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Molecular weight:
38,534 Da
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Basal Isoelectric point:
6.87
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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