SCS-beta a mitochondrial enzyme that catalyzes the phosphorylation of NTP, where N = adenosine or guanosine, in the tricarboxylic acid cycle. Catalyzes the following: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - propanoate; EC; Ligase; Mitochondrial
Chromosomal Location of Human Ortholog: 13q14.2
Cellular Component:  mitochondrial matrix; mitochondrion
Molecular Function:  ATP binding; magnesium ion binding; protein binding; succinate-CoA ligase (ADP-forming) activity
Biological Process:  succinate metabolic process; succinyl-CoA metabolic process; succinyl-CoA pathway; tricarboxylic acid cycle
Disease: Mitochondrial Dna Depletion Syndrome 5 (encephalomyopathic With Or Without Methylmalonic Aciduria)
Reference #:  Q9P2R7 (UniProtKB)
Alt. Names/Synonyms: A-BETA; ATP-specific succinyl-CoA synthetase subunit beta; ATP-specific succinyl-CoA synthetase, beta subunit; Renal carcinoma antigen NY-REN-39; SCS-betaA; SUCB1; Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; succinate-CoA ligase, ADP-forming, beta subunit; Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase beta-A chain; SUCLA2
Gene Symbols: SUCLA2
Molecular weight: 50,317 Da
Basal Isoelectric point: 7.05  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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