ZCCHC3 Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses. Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as DDX58/RIG-I, IFIH1/MDA5 and CGAS. Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus. Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation. Promotes sensing of viral RNA by RIG-I-like receptors proteins DDX58/RIG-I and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of DDX58/RIG-I and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of DDX58/RIG-I and IFIH1/MDA5. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; RNA-binding
Chromosomal Location of human Ortholog: 20p13
Cellular Component:  cytoplasm
Molecular Function:  double-stranded DNA binding; protein binding; zinc ion binding
Biological Process:  activation of innate immune response; cellular response to exogenous dsRNA; defense response to virus; detection of virus; innate immune response; positive regulation of RIG-I signaling pathway; positive regulation of type I interferon production
Reference #:  Q9NUD5 (UniProtKB)
Alt. Names/Synonyms: C20orf99; MGC104290; ZCCHC3; ZCHC3; Zinc finger CCHC domain-containing protein 3; zinc finger CCHC-type containing 3; zinc finger, CCHC domain containing 3
Gene Symbols: ZCCHC3
Molecular weight: 43,547 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein