PHPT1 a phosphohistidine phosphatase. Present preferentially in heart and skeletal muscle. Insensitive to inhibition by okadaic acid and EDTA. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - fructose and mannose; Cofactor and Vitamin Metabolism - riboflavin; Cofactor and Vitamin Metabolism - thiamine; EC 3.1.3.-; Motility/polarity/chemotaxis; Phosphatase
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component:  cytosol
Molecular Function:  calcium channel inhibitor activity; ion channel binding; protein binding; protein histidine phosphatase activity
Biological Process:  negative regulation of ATP citrate synthase activity; negative regulation of lyase activity; negative regulation of T cell receptor signaling pathway; peptidyl-histidine dephosphorylation; positive regulation of cell motility; positive regulation of insulin secretion involved in cellular response to glucose stimulus; protein dephosphorylation; regulation of actin cytoskeleton reorganization
Reference #:  Q9NRX4 (UniProtKB)
Alt. Names/Synonyms: 14 kDa phosphohistidine phosphatase; 1700008C22Rik; bA216L13.10; CGI-202; DKFZp564M173; HSPC141; Phosphohistidine phosphatase 1; phosphohistidine phosphatase 14kDa; PHP14; PHPT1; Protein janus-A homolog; sex-regulated protein janus-a
Gene Symbols: PHPT1
Molecular weight: 13,833 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein