ELP3 Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in acetylation of alpha-tubulin. May also have a methyltransferase activity. Involved in cell migration. Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. Belongs to the ELP3 family. Expressed in the cerebellum and spinal motor neurons. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC
Chromosomal Location of Human Ortholog: 8p21.1
Cellular Component:  cytoplasm; Elongator holoenzyme complex; nucleolus; transcription elongation factor complex
Molecular Function:  acetyltransferase activity; histone acetyltransferase activity; iron-sulfur cluster binding; metal ion binding; phosphorylase kinase regulator activity; protein binding
Biological Process:  central nervous system development; histone acetylation; neuron migration; positive regulation of cell migration; regulation of protein kinase activity; regulation of transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter; tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
Reference #:  Q9H9T3 (UniProtKB)
Alt. Names/Synonyms: elongation protein 3 homolog; elongation protein 3 homolog (S. cerevisiae); elongator acetyltransferase complex subunit 3; Elongator complex protein 3; ELP3; FLJ10422; hELP3; KAT9; Protein lysine acetyltransferase ELP3; tRNA uridine(34) acetyltransferase
Gene Symbols: ELP3
Molecular weight: 62,259 Da
Basal Isoelectric point: 9.04  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB