ESYT1 Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Belongs to the extended synaptotagmin family. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 12q13.2
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane; extrinsic component of cytoplasmic side of plasma membrane
Molecular Function:  calcium ion binding; calcium-dependent phospholipid binding; identical protein binding; phosphatidylcholine binding; phosphatidylethanolamine binding; phosphatidylinositol binding; phospholipid transfer activity; protein binding
Biological Process:  endoplasmic reticulum-plasma membrane tethering; intermembrane lipid transfer; phospholipid transport
Reference #:  Q9BSJ8 (UniProtKB)
Alt. Names/Synonyms: E-Syt1; ESYT1; extended synaptotagmin 1; extended synaptotagmin like protein 1; extended synaptotagmin protein 1; Extended synaptotagmin-1; extended synaptotagmin-like protein 1; FAM62A; family with sequence similarity 62 (C2 domain containing), member A; KIAA0747; MBC2; Membrane-bound C2 domain-containing protein
Gene Symbols: ESYT1
Molecular weight: 122,856 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein