PSMB7 Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity. Belongs to the peptidase T1B family. Expressed at a low level in colonic mucosa. Up-regulated in colorectal cancer tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: EC 3.4.25.1; Protease; Proteasome complex

Chromosomal Location of human Ortholog: 9q33.3

Cellular Component: cytoplasm; cytosol; extracellular region; ficolin-1-rich granule lumen; nuclear body; nucleoplasm; nucleus; proteasome complex; proteasome core complex; proteasome core complex, beta-subunit complex; secretory granule lumen

Molecular Function: endopeptidase activity; protein binding; threonine-type endopeptidase activity

Biological Process: proteasomal protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process

Reference #: Q99436 (UniProtKB)

Alt. Names/Synonyms: epididymis secretory sperm binding protein; Macropain chain Z; Multicatalytic endopeptidase complex chain Z; proteasome (prosome, macropain) subunit, beta type, 7; proteasome 20S subunit beta 7; proteasome catalytic subunit 2; proteasome subunit alpha; proteasome subunit beta 7; Proteasome subunit beta type-7; proteasome subunit beta2; Proteasome subunit Z; protein serine kinase c17; PSB7; PSMB7; Z

Gene Symbols: PSMB7

Molecular weight: 29,965 Da

Basal Isoelectric point: 7.58 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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PSMB7

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