BICD2 Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex. Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis. Belongs to the BicD family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q22.31
Cellular Component:  annulate lamellae; centrosome; cytoplasm; cytoplasmic vesicle; cytosol; Golgi apparatus; nuclear envelope; nuclear pore; plasma membrane
Molecular Function:  cytoskeletal adaptor activity; dynactin binding; dynein complex binding; dynein light intermediate chain binding; protein binding; Rab GTPase binding
Biological Process:  centrosome localization; microtubule anchoring at microtubule organizing center; minus-end-directed organelle transport along microtubule; mRNA transport; protein localization to Golgi apparatus; protein transport; regulation of microtubule cytoskeleton organization; retrograde vesicle-mediated transport, Golgi to ER
Disease: Spinal Muscular Atrophy, Lower Extremity-predominant, 2, Autosomal Dominant; Spinal Muscular Atrophy, Lower Extremity-predominant, 2b, Prenatal Onset, Autosomal Dominant
Reference #:  Q8TD16 (UniProtKB)
Alt. Names/Synonyms: bA526D8.1; Bic-D 2; bicaudal D homolog 2 (Drosophila); BICD2; coiled-coil protein BICD2; cytoskeleton-like bicaudal D protein homolog 2; homolog of Drosophila bicaudal D; KIAA0699; Protein bicaudal D homolog 2
Gene Symbols: BICD2
Molecular weight: 93,533 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene