PDCD4 Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA. Belongs to the PDCD4 family. Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Tumor suppressor
Chromosomal Location of Human Ortholog: 10q25.2
Cellular Component:  cytoplasm; cytosol; nucleus
Molecular Function:  protein binding; RNA binding
Biological Process:  apoptotic process; BMP signaling pathway; cell aging; cellular response to lipopolysaccharide; epithelial to mesenchymal transition involved in cardiac fibroblast development; interleukin-12-mediated signaling pathway; negative regulation of apoptotic process; negative regulation of cell cycle; negative regulation of cytokine production involved in inflammatory response; negative regulation of JUN kinase activity; negative regulation of myofibroblast differentiation; negative regulation of transcription, DNA-templated; negative regulation of vascular smooth muscle cell differentiation; negative regulation of vascular smooth muscle cell proliferation; positive regulation of endothelial cell apoptotic process; positive regulation of inflammatory response; positive regulation of NIK/NF-kappaB signaling; positive regulation of vascular associated smooth muscle cell apoptotic process
Reference #:  Q53EL6 (UniProtKB)
Alt. Names/Synonyms: H731; MGC33046; MGC33047; Neoplastic transformation inhibitor protein; nuclear antigen H731; Nuclear antigen H731-like; PDCD4; programmed cell death 4; programmed cell death 4 (neoplastic transformation inhibitor); Programmed cell death protein 4; Protein 197/15a
Gene Symbols: PDCD4
Molecular weight: 51,735 Da
Basal Isoelectric point: 5.07  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene