TRXR1 Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine; Oxidoreductase
Chromosomal Location of human Ortholog: 12q23.3
Cellular Component:  cytosol; fibrillar center; nucleoplasm
Molecular Function:  electron transfer activity; flavin adenine dinucleotide binding; protein binding; protein disulfide oxidoreductase activity
Biological Process:  cell proliferation; cellular oxidant detoxification; cellular response to oxidative stress; electron transport chain; mesoderm formation; nucleobase-containing small molecule interconversion; regulation of lipid metabolic process; selenium compound metabolic process; signal transduction
Reference #:  Q16881 (UniProtKB)
Alt. Names/Synonyms: Gene associated with retinoic and IFN-induced mortality 12 protein; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; GRIM12; KDRF; KM-102-derived reductase-like factor; MGC9145; oxidoreductase; selenoprotein TXNRD1; testis tissue sperm-binding protein Li 46a; thioredoxin reductase 1; Thioredoxin reductase 1, cytoplasmic; thioredoxin reductase GRIM-12; Thioredoxin reductase TR1; TR; TR1; TRXR1; TXNR; TXNRD1
Gene Symbols: TXNRD1
Molecular weight: 70,906 Da
Basal Isoelectric point: 7.16  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein