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SF3A1
subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; RNA splicing; RNA-binding; Spliceosome |
| Chromosomal Location of Human Ortholog: 22q12.2 |
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Cellular Component:
catalytic step 2 spliceosome; nuclear speck; nucleoplasm; snRNP U2; spliceosomal complex; U2-type prespliceosome; U2-type spliceosomal complex
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Molecular Function:
protein binding; RNA binding
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Biological Process:
mRNA processing; mRNA splicing, via spliceosome; nuclear mRNA 3'-splice site recognition
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Reference #:
Q15459
(UniProtKB)
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Alt. Names/Synonyms: pre-mRNA processing 21; pre-mRNA splicing factor SF3a (120 kDa subunit); PRP21; PRPF21; SAP 114; SAP114; SF3A1; SF3a120; spliceosome associated protein 114; Spliceosome-associated protein 114; splicing factor 3 subunit 1; Splicing factor 3A subunit 1; splicing factor 3a, subunit 1, 120kDa
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Gene Symbols: SF3A1
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Molecular weight:
88,886 Da
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Basal Isoelectric point:
5.15
Predict pI for various phosphorylation states
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