SF3A1 subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component:  catalytic step 2 spliceosome; nuclear speck; nucleoplasm; nucleus; spliceosomal complex; U2 snRNP; U2-type precatalytic spliceosome; U2-type prespliceosome; U2-type spliceosomal complex
Molecular Function:  protein binding; RNA binding
Biological Process:  mRNA 3'-splice site recognition; mRNA processing; mRNA splicing, via spliceosome; U2-type prespliceosome assembly
Reference #:  Q15459 (UniProtKB)
Alt. Names/Synonyms: pre-mRNA processing 21; pre-mRNA splicing factor SF3a (120 kDa subunit); PRP21; PRPF21; SAP 114; SAP114; SF3A1; SF3a120; spliceosome associated protein 114; Spliceosome-associated protein 114; splicing factor 3 subunit 1; Splicing factor 3A subunit 1; splicing factor 3a, subunit 1, 120kDa
Gene Symbols: SF3A1
Molecular weight: 88,886 Da
Basal Isoelectric point: 5.15  Predict pI for various phosphorylation states
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SF3A1

Protein Structure Not Found.


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