|
SF3A1
subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Note: This description may include information from UniProtKB.
|
| Protein type: Nuclear receptor co-regulator; RNA splicing; RNA-binding; Spliceosome |
| Chromosomal Location of Human Ortholog: 22q12.2 |
|
Cellular Component:
catalytic step 2 spliceosome; nuclear speck; nucleoplasm; nucleus; spliceosomal complex; U2 snRNP; U2-type precatalytic spliceosome; U2-type prespliceosome; U2-type spliceosomal complex
|
|
Molecular Function:
protein binding; RNA binding
|
|
Biological Process:
mRNA 3'-splice site recognition; mRNA processing; mRNA splicing, via spliceosome; U2-type prespliceosome assembly
|
|
Reference #:
Q15459
(UniProtKB)
|
|
Alt. Names/Synonyms: pre-mRNA processing 21; pre-mRNA splicing factor SF3a (120 kDa subunit); PRP21; PRPF21; SAP 114; SAP114; SF3A1; SF3a120; spliceosome associated protein 114; Spliceosome-associated protein 114; splicing factor 3 subunit 1; Splicing factor 3A subunit 1; splicing factor 3a, subunit 1, 120kDa
|
|
Gene Symbols: SF3A1
|
|
Molecular weight:
88,886 Da
|
|
Basal Isoelectric point:
5.15
Predict pI for various phosphorylation states
|
