SF3B4 Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. Belongs to the SF3B4 family. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 1q21.2
Cellular Component:  nucleoplasm; nucleus; spliceosomal complex; U12-type spliceosomal complex; U2-type precatalytic spliceosome
Molecular Function:  protein binding
Biological Process:  mRNA processing; mRNA splicing, via spliceosome; RNA splicing; RNA splicing, via transesterification reactions
Disease: Acrofacial Dysostosis 1, Nager Type
Reference #:  Q15427 (UniProtKB)
Alt. Names/Synonyms: AFD1; Hsh49; MGC10828; pre-mRNA splicing factor SF3b 49 kDa subunit; Pre-mRNA-splicing factor SF3b 49 kDa subunit; SAP 49; SAP49; SF3B4; SF3b49; SF3b50; spliceosomal protein; spliceosome-associated protein (U2 snRNP); Spliceosome-associated protein 49; Splicing factor 3B subunit 4; splicing factor 3b, subunit 4, 49kD; splicing factor 3b, subunit 4, 49kDa
Gene Symbols: SF3B4
Molecular weight: 44,386 Da
Basal Isoelectric point: 8.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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