TRIM25 Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58 and IFIH1. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Mediates 'Lys-63'-linked polyubiquitination of IFIH1. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3. Expressed in breast tumors (at protein level). Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: EC; EC 6.3.2.n3; Ligase; Nuclear receptor co-regulator; Transcription factor; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 17q22
Cellular Component:  cytosol; nuclear body; nucleoplasm
Molecular Function:  ligase activity; protein binding; ubiquitin protein ligase activity; zinc ion binding
Biological Process:  cellular response to leukemia inhibitory factor; defense response to virus; innate immune response; interferon-gamma-mediated signaling pathway; negative regulation of type I interferon production; negative regulation of viral entry into host cell; negative regulation of viral release from host cell; positive regulation of DNA-binding transcription factor activity; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; protein monoubiquitination; regulation of viral entry into host cell; regulation of viral release from host cell; response to estrogen; response to vitamin D; translesion synthesis; ubiquitin-dependent ERAD pathway; ubiquitin-dependent protein catabolic process; viral process
Reference #:  Q14258 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin/ISG15 ligase TRIM25; EFP; Estrogen-responsive finger protein; RING finger protein 147; RNF147; TRI25; TRIM25; tripartite motif protein TRIM25; tripartite motif-containing 25; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Z147; Zinc finger protein 147; zinc finger protein 147 (estrogen-responsive finger protein); zinc finger protein-147; ZNF147
Gene Symbols: TRIM25
Molecular weight: 70,973 Da
Basal Isoelectric point: 8.44  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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