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eIF3-beta
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Belongs to the eIF-3 subunit I family. Note: This description may include information from UniProtKB.
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| Protein type: Translation; Translation initiation |
| Chromosomal Location of human Ortholog: 1p35.2 |
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Cellular Component:
cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; eukaryotic translation initiation factor 3 complex, eIF3m; synapse
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Molecular Function:
protein binding; RNA binding; translation initiation factor activity
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Biological Process:
cytoplasmic translational initiation; formation of cytoplasmic translation initiation complex; translational initiation
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Reference #:
Q13347
(UniProtKB)
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Alt. Names/Synonyms: eIF-3-beta; eIF3 p36; eIF3-beta; eIF3-p36; EIF3I; EIF3S2; Eukaryotic translation initiation factor 3 subunit 2; Eukaryotic translation initiation factor 3 subunit I; eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD); eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa; eukaryotic translation initiation factor 3, subunit I; predicted protein of HQ2242; PRO2242; TGF-beta receptor-interacting protein 1; TGFbeta receptor-interacting protein 1; TRIP-1; TRIP1
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Gene Symbols: EIF3I
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Molecular weight:
36,502 Da
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Basal Isoelectric point:
5.38
Predict pI for various phosphorylation states
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CST Pathways:
Translational Control
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