PABP 4 Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Belongs to the polyadenylate-binding protein type-1 family. Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Translation
Chromosomal Location of Human Ortholog: 1p34.3
Cellular Component:  cytoplasm; cytoplasmic stress granule; cytosol; nucleus; ribonucleoprotein complex
Molecular Function:  poly(A) binding; poly(U) RNA binding; protein binding
Biological Process:  blood coagulation; myeloid cell development; regulation of mRNA stability; RNA catabolic process; RNA processing; translation
Reference #:  Q13310 (UniProtKB)
Alt. Names/Synonyms: Activated-platelet protein 1; APP-1; APP1; FLJ43938; Inducible poly(A)-binding protein; iPABP; PABP 4; PABP-4; PABP4; PABPC4; poly(A) binding protein cytoplasmic 4; poly(A) binding protein, cytoplasmic 4 (inducible form); Poly(A)-binding protein 4; Polyadenylate-binding protein 4
Gene Symbols: PABPC4
Molecular weight: 70,783 Da
Basal Isoelectric point: 9.31  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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