SF3A3 Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes. Belongs to the SF3A3 family. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 1p34.3
Cellular Component:  catalytic step 2 spliceosome; nuclear speck; nucleoplasm; nucleus; spliceosomal complex; U2 snRNP; U2-type precatalytic spliceosome
Molecular Function:  protein binding; zinc ion binding
Biological Process:  mRNA 3'-splice site recognition; mRNA processing; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; U2-type prespliceosome assembly
Reference #:  Q12874 (UniProtKB)
Alt. Names/Synonyms: pre-mRNA splicing factor SF3a (60kD); PRP9; PRPF9; SAP 61; SAP61; SF3A3; SF3a60; spliceosome associated protein 61; Spliceosome-associated protein 61; Splicing factor 3A subunit 3; splicing factor 3a, subunit 3, 60kDa
Gene Symbols: SF3A3
Molecular weight: 58,849 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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