SF2 a serine-arginine-rich splicing regulatory protein. Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5' and 3' splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice-site-containing pre-mRNA. Extensively phosphorylated on serine residues in the serine-arginine rich region. Three splice variant isoforms have been described. ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 17q22
Cellular Component:  catalytic step 2 spliceosome; cytoplasm; nuclear speck; nucleoplasm; nucleus
Molecular Function:  DNA topoisomerase binding; mRNA binding; protein binding; RNA binding
Biological Process:  alternative mRNA splicing, via spliceosome; mRNA 3'-end processing; mRNA 5'-splice site recognition; mRNA export from nucleus; mRNA processing; mRNA splice site selection; mRNA splicing, via spliceosome; RNA export from nucleus
Reference #:  Q07955 (UniProtKB)
Alt. Names/Synonyms: Alternative-splicing factor 1; ASF; ASF-1; MGC5228; pre-mRNA-splicing factor SF2, P33 subunit; Serine/arginine-rich splicing factor 1; SF2; SF2P33; SFRS1; splicing factor 2; Splicing factor, arginine/serine-rich 1; SRp30a
Gene Symbols: SRSF1
Molecular weight: 27,745 Da
Basal Isoelectric point: 10.37  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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