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GBE1
Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule. Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.18; Transferase |
| Chromosomal Location of human Ortholog: 3p12.2 |
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Cellular Component:
cytoplasm; cytosol
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Molecular Function:
1,4-alpha-glucan branching enzyme activity; 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis); carbohydrate binding; cation binding; hydrolase activity, hydrolyzing O-glycosyl compounds; protein binding
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Biological Process:
generation of precursor metabolites and energy; glycogen biosynthetic process; glycogen metabolic process; negative regulation of neuron apoptotic process
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Disease: Glycogen Storage Disease Iv; Polyglucosan Body Disease, Adult Form
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Reference #:
Q04446
(UniProtKB)
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Alt. Names/Synonyms: 1,4-alpha-glucan branching enzyme 1; 1,4-alpha-glucan-branching enzyme; amylo-(1,4 to 1,6) transglucosidase; amylo-(1,4 to 1,6) transglycosylase; APBD; Brancher enzyme; GBE; GBE1; GLGB; glucan (1,4-alpha-), branching enzyme 1; glycogen branching enzyme; Glycogen-branching enzyme; GSD4
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Gene Symbols: GBE1
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Molecular weight:
80,474 Da
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Basal Isoelectric point:
5.87
Predict pI for various phosphorylation states
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