FABP5 Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors. Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation. May be involved in keratinocyte differentiation. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. Keratinocytes; highly expressed in psoriatic skin. Note: This description may include information from UniProtKB.
Protein type: Lipid-binding
Chromosomal Location of Human Ortholog: 8q21.13
Cellular Component:  azurophil granule lumen; cell junction; cytoplasm; cytosol; extracellular region; nucleoplasm; nucleus; plasma membrane; postsynaptic density; postsynaptic membrane; secretory granule membrane; synapse
Molecular Function:  fatty acid binding; identical protein binding; lipid binding; protein binding; retinoic acid binding
Biological Process:  epidermis development; glucose homeostasis; glucose metabolic process; lipid metabolic process; negative regulation of glucose transmembrane transport; neutrophil degranulation; phosphatidylcholine biosynthetic process; positive regulation of cold-induced thermogenesis; positive regulation of peroxisome proliferator activated receptor signaling pathway; regulation of prostaglandin biosynthetic process; regulation of retrograde trans-synaptic signaling by endocanabinoid; regulation of sensory perception of pain; triglyceride catabolic process
Reference #:  Q01469 (UniProtKB)
Alt. Names/Synonyms: E-FABP; EFABP; Epidermal-type fatty acid-binding protein; FABP5; fatty acid binding protein 5 (psoriasis-associated); Fatty acid-binding protein 5; Fatty acid-binding protein, epidermal; PA-FABP; PAFABP; Psoriasis-associated fatty acid-binding protein homolog
Gene Symbols: FABP5
Molecular weight: 15,164 Da
Basal Isoelectric point: 6.6  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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FABP5

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene