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FABP5
Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors. Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation. May be involved in keratinocyte differentiation. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. Keratinocytes; highly expressed in psoriatic skin. Note: This description may include information from UniProtKB.
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| Protein type: Lipid-binding |
| Chromosomal Location of human Ortholog: 8q21.13 |
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Cellular Component:
azurophil granule lumen; cytoplasm; cytosol; extracellular region; nucleoplasm; nucleus; plasma membrane; postsynaptic density; secretory granule membrane; synapse
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Molecular Function:
fatty acid binding; identical protein binding; lipid binding; long-chain fatty acid transporter activity; protein binding; retinoic acid binding
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Biological Process:
epidermis development; fatty acid transport; glucose homeostasis; glucose metabolic process; lipid metabolic process; lipid transport across blood-brain barrier; long-chain fatty acid transport; negative regulation of glucose transmembrane transport; phosphatidylcholine biosynthetic process; positive regulation of cold-induced thermogenesis; positive regulation of peroxisome proliferator activated receptor signaling pathway; regulation of prostaglandin biosynthetic process; regulation of retrograde trans-synaptic signaling by endocanabinoid; regulation of sensory perception of pain
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Reference #:
Q01469
(UniProtKB)
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Alt. Names/Synonyms: E-FABP; EFABP; Epidermal-type fatty acid-binding protein; FABP5; fatty acid binding protein 5; fatty acid binding protein 5 (psoriasis-associated); Fatty acid-binding protein 5; Fatty acid-binding protein, epidermal; KFABP; PA-FABP; PAFABP; Psoriasis-associated fatty acid-binding protein homolog
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Gene Symbols: FABP5
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Molecular weight:
15,164 Da
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Basal Isoelectric point:
6.6
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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