RAB11B The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis. Belongs to the small GTPase superfamily. Rab family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of rat Ortholog: 7q13
Cellular Component:  anchored component of synaptic vesicle membrane; cell junction; cytoplasm; cytoplasmic vesicle; endosome; phagocytic vesicle; phagocytic vesicle membrane; recycling endosome; recycling endosome membrane; synaptic vesicle
Molecular Function:  GDP binding; GTP binding; GTPase activity; myosin V binding
Biological Process:  amyloid-beta clearance by transcytosis; cellular response to acidic pH; constitutive secretory pathway; establishment of protein localization to membrane; exocytosis; insulin secretion involved in cellular response to glucose stimulus; intracellular protein transport; melanosome transport; Rab protein signal transduction; receptor recycling; regulated exocytosis; regulation of anion transport; regulation of endocytic recycling; regulation of protein localization to cell surface; retrograde transport, endosome to plasma membrane; transferrin transport
Reference #:  O35509 (UniProtKB)
Alt. Names/Synonyms: Rab11b; RAB11B, member RAS oncogene family; Ras-related protein Rab-11B; RB11B
Gene Symbols: Rab11b
Molecular weight: 24,489 Da
Basal Isoelectric point: 5.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene