RAB11B
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis. Belongs to the small GTPase superfamily. Rab family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab |
Chromosomal Location of human Ortholog: 19p13.2 |
Cellular Component:
cytosol; Golgi apparatus; phagocytic vesicle; phagocytic vesicle membrane; recycling endosome; recycling endosome membrane; synaptic vesicle; synaptic vesicle membrane
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Molecular Function:
G protein activity; GDP binding; GTP binding; GTPase activity; myosin V binding; protein binding
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Biological Process:
amyloid-beta clearance by transcytosis; cellular response to acidic pH; constitutive secretory pathway; endocytic recycling; establishment of protein localization to membrane; insulin secretion involved in cellular response to glucose stimulus; melanosome transport; receptor recycling; regulated exocytosis; regulation of endocytic recycling; regulation of monoatomic anion transport; regulation of protein localization to cell surface; transferrin transport
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Disease: Neurodevelopmental Disorder With Ataxic Gait, Absent Speech, And Decreased Cortical White Matter
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Reference #:
Q15907
(UniProtKB)
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Alt. Names/Synonyms: GTP-binding protein YPT3; H-YPT3; MGC133246; NDAGSCW; RAB11B; RAB11B, member of RAS oncogene family; RAB11B, member RAS oncogene family; Ras-related protein Rab-11B; RB11B; YPT3
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Gene Symbols: RAB11B
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Molecular weight:
24,489 Da
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Basal Isoelectric point:
5.64
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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