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IST1
ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST. Belongs to the IST1 family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; Vesicle |
| Chromosomal Location of human Ortholog: 16q22.2 |
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Cellular Component:
azurophil granule lumen; centrosome; cytosol; endoplasmic reticulum-Golgi intermediate compartment; extracellular region; Flemming body; intracellular membrane-bounded organelle; midbody; nuclear envelope
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Molecular Function:
MIT domain binding; protein binding; protein domain specific binding; protein-containing complex binding
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Biological Process:
abscission; cell division; collateral sprouting; cytoskeleton-dependent cytokinesis; ESCRT III complex disassembly; establishment of protein localization; multivesicular body assembly; positive regulation of collateral sprouting; positive regulation of proteolysis; protein localization; protein transport; viral capsid secondary envelopment; viral release from host cell
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Reference #:
P53990
(UniProtKB)
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Alt. Names/Synonyms: CHMP8; hIST1; increased sodium tolerance 1 homolog; increased sodium tolerance-1; IST1; IST1 factor associated with ESCRT-III; IST1 homolog; IST1, endosomal sorting complex required for transport-III component; IST1, ESCRT-III associated factor; KIAA0174; MGC117220; OLC1; overexpressed in lung cancer 1; Putative MAPK-activating protein PM28
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Gene Symbols: IST1
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Molecular weight:
39,751 Da
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Basal Isoelectric point:
5.22
Predict pI for various phosphorylation states
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