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COPA
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor. Uniformly expressed in a wide range of adult and fetal tissues. Xenin is found in gastric, duodenal and jejunal mucosa. Circulates in the blood. Seems to be confined to specific endocrine cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Vesicle |
| Chromosomal Location of human Ortholog: 1q23.2 |
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Cellular Component:
COPI vesicle coat; cytoplasm; cytosol; endoplasmic reticulum membrane; extracellular space; Golgi membrane; growth cone; transport vesicle
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Molecular Function:
hormone activity; protein binding; structural molecule activity
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Biological Process:
endoplasmic reticulum to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport; intracellular protein transport; pancreatic juice secretion; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; signal transduction
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Disease: Autoimmune Interstitial Lung, Joint, And Kidney Disease
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Reference #:
P53621
(UniProtKB)
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Alt. Names/Synonyms: AILJK; alpha coat protein; Alpha-coat protein; Alpha-COP; coatomer protein complex subunit alpha; coatomer protein complex, subunit alpha; Coatomer subunit alpha; COPA; COPI coat complex subunit alpha; FLJ26320; HEP-COP; HEPCOP; Proxenin; Xenin; Xenopsin-related peptide
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Gene Symbols: COPA
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Molecular weight:
138,346 Da
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Basal Isoelectric point:
7.7
Predict pI for various phosphorylation states
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