SMS Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). Belongs to the spermidine/spermine synthase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - cysteine and methionine; EC; Other Amino Acids Metabolism - beta-alanine; Other Amino Acids Metabolism - glutathione; Transferase
Chromosomal Location of human Ortholog: Xp22.11
Cellular Component:  cytosol
Molecular Function:  spermine synthase activity
Biological Process:  methionine metabolic process; polyamine metabolic process; spermine biosynthetic process
Disease: Mental Retardation, X-linked, Syndromic, Snyder-robinson Type
Reference #:  P52788 (UniProtKB)
Alt. Names/Synonyms: MRSR; SMS; Spermidine aminopropyltransferase; Spermine synthase; SPMSY; SpS; SPSY; SRS
Gene Symbols: SMS
Molecular weight: 41,268 Da
Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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