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SMS
Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). Belongs to the spermidine/spermine synthase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - cysteine and methionine; EC 2.5.1.22; Other Amino Acids Metabolism - beta-alanine; Other Amino Acids Metabolism - glutathione; Transferase |
| Chromosomal Location of human Ortholog: Xp22.11 |
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Cellular Component:
cytosol
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Molecular Function:
spermine synthase activity
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Biological Process:
methionine metabolic process; polyamine metabolic process; spermine biosynthetic process
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Disease: Mental Retardation, X-linked, Syndromic, Snyder-robinson Type
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Reference #:
P52788
(UniProtKB)
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Alt. Names/Synonyms: MRSR; SMS; Spermidine aminopropyltransferase; Spermine synthase; SPMSY; SpS; SPSY; SRS
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Gene Symbols: SMS
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Molecular weight:
41,268 Da
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Basal Isoelectric point:
4.87
Predict pI for various phosphorylation states
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