PRI2 DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. Belongs to the eukaryotic-type primase large subunit family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.7.-; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transferase
Chromosomal Location of Human Ortholog: 6p11.2
Cellular Component:  nucleoplasm
Molecular Function:  4 iron, 4 sulfur cluster binding; metal ion binding
Biological Process:  DNA replication initiation; DNA replication, synthesis of RNA primer; G1/S transition of mitotic cell cycle; telomere maintenance via semi-conservative replication
Reference #:  P49643 (UniProtKB)
Alt. Names/Synonyms: dJ422B11.1.1; DNA primase 58 kDa subunit; DNA primase large subunit; DNA primase polypeptide 2; DNA primase subunit p58; MGC75142; p58; polypeptide 2A, p58; PRI2; PRIM2; PRIM2A; primase polypeptide 2A, 58kDa; primase, DNA, polypeptide 2 (58kDa); primase, polypeptide 2A (58kD)
Gene Symbols: PRIM2
Molecular weight: 58,806 Da
Basal Isoelectric point: 7.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PRI2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene