CARS Belongs to the class-I aminoacyl-tRNA synthetase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Aminoacyl-tRNA synthetase; EC; Ligase; Oncoprotein; Translation; Translation regulation
Chromosomal Location of human Ortholog: 11p15.4
Cellular Component:  cytoplasm; cytosol
Molecular Function:  ATP binding; cysteine-tRNA ligase activity; identical protein binding; metal ion binding; protein binding; tRNA binding
Biological Process:  cysteinyl-tRNA aminoacylation
Disease: Microcephaly, Developmental Delay, And Brittle Hair Syndrome
Reference #:  P49589 (UniProtKB)
Alt. Names/Synonyms: CARS; CARS1; CysRS; cysteine translase; cysteine tRNA ligase 1, cytoplasmic; Cysteine--tRNA ligase; Cysteine--tRNA ligase, cytoplasmic; cysteine-tRNA ligase; cysteinyl-tRNA synthetase; cysteinyl-tRNA synthetase 1; Cysteinyl-tRNA synthetase, cytoplasmic; MCDDBH; MDBH; MGC:11246; SYCC
Gene Symbols: CARS1
Molecular weight: 85,473 Da
Basal Isoelectric point: 6.31  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein