SHB iso2 Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 9p13.1
Cellular Component:  cytoplasmic ribonucleoprotein granule; cytosol; nucleoplasm; plasma membrane
Molecular Function:  phosphotyrosine residue binding; protein binding; SH3/SH2 adaptor activity
Biological Process:  angiogenesis; apoptotic process; cell differentiation; positive regulation of signal transduction; signal transduction; vascular endothelial growth factor receptor signaling pathway
Reference #:  Q15464-2 (UniProtKB)
Alt. Names/Synonyms: bA3J10.2; SH2 domain containing adaptor protein B; SH2 domain-containing adapter protein B; SHB; SHB (Src homology 2 domain containing) adaptor protein B; SHB adaptor protein (a Src homology 2 protein); SHB iso2; Src homology 2 domain containing adaptor protein B
Gene Symbols: SHB
Molecular weight: 30,703 Da
Basal Isoelectric point: 9.16  Predict pI for various phosphorylation states
Select Structure to View Below

SHB iso2

Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein