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ITPA iso2
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.1.19; Hydrolase; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes |
| Chromosomal Location of human Ortholog: 20p13 |
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Cellular Component:
cytoplasm; cytosol; intracellular membrane-bounded organelle; nucleoplasm
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Molecular Function:
dITP diphosphatase activity; identical protein binding; ITP diphosphatase activity; metal ion binding; nucleoside triphosphate diphosphatase activity; nucleotide binding; XTP diphosphatase activity
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Biological Process:
chromosome organization; deoxyribonucleoside triphosphate catabolic process; ITP catabolic process; nucleoside triphosphate catabolic process
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Reference #:
Q9BY32-2
(UniProtKB)
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Alt. Names/Synonyms: C20orf37; dJ794I6.3; epididymis secretory sperm binding protein; HLC14-06-P; Inosine triphosphatase; inosine triphosphatase (nucleoside triphosphate pyrophosphatase); Inosine triphosphate pyrophosphatase; inosine triphosphate pyrophosphohydrolase; ITPA; ITPA iso2; ITPase; My049; Non-canonical purine NTP pyrophosphatase; Non-standard purine NTP pyrophosphatase; NTPase; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase; Putative oncogene protein hlc14-06-p
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Gene Symbols: ITPA
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Molecular weight:
19,603 Da
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Basal Isoelectric point:
5.08
Predict pI for various phosphorylation states
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