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QARS
Glutamine--tRNA ligase. Plays a critical role in brain development. Belongs to the class-I aminoacyl-tRNA synthetase family. Highly expressed in fetal cerebral cortex, particularly in the ventricular zone, inner subventricular zone, outer subventricular zone, and cortical plate. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Aminoacyl-tRNA synthetase; EC 6.1.1.18; Ligase; Mitochondrial; Translation; Translation regulation |
| Chromosomal Location of human Ortholog: 3p21.31 |
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Cellular Component:
aminoacyl-tRNA synthetase multienzyme complex; cytoplasm; cytosol; mitochondrial matrix; protein-containing complex
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Molecular Function:
ATP binding; glutamine-tRNA ligase activity; protein binding; protein kinase binding; protein kinase inhibitor activity
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Biological Process:
brain development; glutaminyl-tRNA aminoacylation; negative regulation of apoptotic signaling pathway; negative regulation of DNA-templated transcription; negative regulation of protein kinase activity; negative regulation of stress-activated MAPK cascade; tRNA aminoacylation for protein translation
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Disease: Microcephaly, Progressive, With Seizures And Cerebral And Cerebellar Atrophy
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Reference #:
P47897
(UniProtKB)
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Alt. Names/Synonyms: GlnRS; glutamine tRNA ligase; Glutamine--tRNA ligase; glutamine-tRNA synthetase; Glutaminyl-tRNA synthetase; glutaminyl-tRNA synthetase 1; MSCCA; PRO2195; QARS; QARS1; SYQ
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Gene Symbols: QARS1
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Molecular weight:
87,799 Da
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Basal Isoelectric point:
6.71
Predict pI for various phosphorylation states
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