QARS Glutamine--tRNA ligase. Plays a critical role in brain development. Belongs to the class-I aminoacyl-tRNA synthetase family. Highly expressed in fetal cerebral cortex, particularly in the ventricular zone, inner subventricular zone, outer subventricular zone, and cortical plate. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Aminoacyl-tRNA synthetase; EC; Ligase; Mitochondrial; Translation; Translation regulation
Chromosomal Location of human Ortholog: 3p21.31
Cellular Component:  aminoacyl-tRNA synthetase multienzyme complex; cytoplasm; cytosol; mitochondrial matrix; protein-containing complex
Molecular Function:  ATP binding; glutamine-tRNA ligase activity; protein binding; protein kinase binding; protein kinase inhibitor activity
Biological Process:  brain development; glutaminyl-tRNA aminoacylation; negative regulation of apoptotic signaling pathway; negative regulation of DNA-templated transcription; negative regulation of protein kinase activity; negative regulation of stress-activated MAPK cascade; tRNA aminoacylation for protein translation
Disease: Microcephaly, Progressive, With Seizures And Cerebral And Cerebellar Atrophy
Reference #:  P47897 (UniProtKB)
Alt. Names/Synonyms: GlnRS; glutamine tRNA ligase; Glutamine--tRNA ligase; glutamine-tRNA synthetase; Glutaminyl-tRNA synthetase; glutaminyl-tRNA synthetase 1; MSCCA; PRO2195; QARS; QARS1; SYQ
Gene Symbols: QARS1
Molecular weight: 87,799 Da
Basal Isoelectric point: 6.71  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene