QARS Glutamine--tRNA ligase. Plays a critical role in brain development. Belongs to the class-I aminoacyl-tRNA synthetase family. Highly expressed in fetal cerebral cortex, particularly in the ventricular zone, inner subventricular zone, outer subventricular zone, and cortical plate. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Aminoacyl-tRNA synthetase; EC 6.1.1.18; Ligase; Mitochondrial; Translation; Translation regulation
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component:  aminoacyl-tRNA synthetase multienzyme complex; cytoplasm; cytosol; mitochondrial matrix; protein-containing complex
Molecular Function:  ATP binding; glutamine-tRNA ligase activity; protein binding; protein kinase binding; protein kinase inhibitor activity
Biological Process:  brain development; glutaminyl-tRNA aminoacylation; negative regulation of apoptotic signaling pathway; negative regulation of protein kinase activity; negative regulation of stress-activated MAPK cascade; negative regulation of transcription, DNA-templated; tRNA aminoacylation for protein translation
Disease: Microcephaly, Progressive, With Seizures And Cerebral And Cerebellar Atrophy
Reference #:  P47897 (UniProtKB)
Alt. Names/Synonyms: GlnRS; glutamine tRNA ligase; Glutamine--tRNA ligase; glutamine-tRNA synthetase; Glutaminyl-tRNA synthetase; PRO2195; QARS; SYQ
Gene Symbols: QARS
Molecular weight: 87,799 Da
Basal Isoelectric point: 6.71  Predict pI for various phosphorylation states
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QARS

Protein Structure Not Found.


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