RPT3 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Belongs to the AAA ATPase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component:  cytosol; inclusion body; nucleoplasm; nucleus; proteasome accessory complex; proteasome complex
Molecular Function:  ATP binding; ATPase activity; proteasome-activating ATPase activity; protein binding
Biological Process:  anaphase-promoting complex-dependent catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; blastocyst development; Fc-epsilon receptor signaling pathway; interleukin-1-mediated signaling pathway; MAPK cascade; negative regulation of canonical Wnt signaling pathway; negative regulation of G2/M transition of mitotic cell cycle; NIK/NF-kappaB signaling; positive regulation of canonical Wnt signaling pathway; positive regulation of proteasomal protein catabolic process; post-translational protein modification; proteasome-mediated ubiquitin-dependent protein catabolic process; protein deubiquitination; protein polyubiquitination; proteolysis; regulation of cellular amino acid metabolic process; regulation of hematopoietic stem cell differentiation; regulation of mitotic cell cycle phase transition; regulation of mRNA stability; regulation of transcription from RNA polymerase II promoter in response to hypoxia; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; transmembrane transport; tumor necrosis factor-mediated signaling pathway; Wnt signaling pathway, planar cell polarity pathway
Reference #:  P43686 (UniProtKB)
Alt. Names/Synonyms: 26S protease regulatory subunit 6B; 26S proteasome AAA-ATPase subunit RPT3; 26S proteasome regulatory subunit 6B; MB67 interacting protein; MB67-interacting protein; MGC13687; MGC23214; MGC8570; MIP224; protease 26S subunit 6; proteasome (prosome, macropain) 26S subunit, ATPase, 4; Proteasome 26S subunit ATPase 4; proteasome 26S subunit, ATPase 4; PRS6B; PSMC4; RPT3; S6; Tat-binding protein 7; TBP-7; TBP7
Gene Symbols: PSMC4
Molecular weight: 47,366 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
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RPT3

Protein Structure Not Found.


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