RAI1 iso3 Transcriptional regulator of the circadian clock components: CLOCK, ARNTL/BMAL1, ARNTL2/BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. Expressed in all tissues examined with higher expression in the heart and brain. No expression was seen in the corpus callosum of the brain. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component:  mitochondrion; nucleoplasm; nucleus
Molecular Function:  enhancer binding; metal ion binding; protein binding
Biological Process:  circadian regulation of gene expression; negative regulation of multicellular organism growth; positive regulation of transcription, DNA-templated; skeletal system development
Reference #:  Q7Z5J4-3 (UniProtKB)
Alt. Names/Synonyms: KIAA1820; RAI1; RAI1 iso3; retinoic acid induced 1; Retinoic acid-induced protein 1; SMCR; Smith-Magenis syndrome chromosome region; SMS
Gene Symbols: RAI1
Molecular weight: 175,343 Da
Basal Isoelectric point: 9.26  Predict pI for various phosphorylation states
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RAI1 iso3

Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene