PBEF Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression. Belongs to the NAPRTase family. Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cytokine; EC; Transferase
Chromosomal Location of Human Ortholog: 7q22.3
Cellular Component:  cell junction; cytosol; nuclear speck; plasma membrane
Molecular Function:  cytokine activity; drug binding; identical protein binding; nicotinamide phosphoribosyltransferase activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity; protein binding; protein homodimerization activity
Biological Process:  aging; cell-cell signaling; cellular response to amyloid-beta; cellular response to ionizing radiation; cellular response to oxygen-glucose deprivation; circadian regulation of gene expression; circadian rhythm; female pregnancy; microglial cell activation; NAD biosynthesis via nicotinamide riboside salvage pathway; negative regulation of autophagy; negative regulation of cellular senescence; neuron death; positive regulation of cell proliferation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of smooth muscle cell proliferation; positive regulation of transcription by RNA polymerase II; regulation of lung blood pressure; regulation of signaling receptor activity; response to D-galactose; response to organic cyclic compound; signal transduction
Reference #:  P43490 (UniProtKB)
Alt. Names/Synonyms: 1110035O14Rik; DKFZp666B131; MGC117256; NAmPRTase; NAMPT; Nicotinamide phosphoribosyltransferase; PBEF; PBEF1; Pre-B cell-enhancing factor; pre-B-cell colony enhancing factor 1; Pre-B-cell colony-enhancing factor 1; VF; Visfatin
Gene Symbols: NAMPT
Molecular weight: 55,521 Da
Basal Isoelectric point: 6.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene