PBEF Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression. Belongs to the NAPRTase family. Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues. Note: This description may include information from UniProtKB.

Protein type: Cell cycle regulation; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cytokine; EC 2.4.2.12; Transferase

Chromosomal Location of Human Ortholog: 7q22.3

Cellular Component: cell junction; cytosol; nuclear speck; plasma membrane

Molecular Function: cytokine activity; drug binding; identical protein binding; nicotinamide phosphoribosyltransferase activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity; protein binding; protein homodimerization activity

Biological Process: aging; cell-cell signaling; cellular response to amyloid-beta; cellular response to ionizing radiation; cellular response to oxygen-glucose deprivation; circadian regulation of gene expression; circadian rhythm; female pregnancy; microglial cell activation; NAD biosynthesis via nicotinamide riboside salvage pathway; negative regulation of autophagy; negative regulation of cellular senescence; neuron death; positive regulation of cell proliferation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of smooth muscle cell proliferation; positive regulation of transcription by RNA polymerase II; regulation of lung blood pressure; regulation of signaling receptor activity; response to D-galactose; response to organic cyclic compound; signal transduction

Reference #: P43490 (UniProtKB)

Alt. Names/Synonyms: 1110035O14Rik; DKFZp666B131; MGC117256; NAmPRTase; NAMPT; Nicotinamide phosphoribosyltransferase; PBEF; PBEF1; Pre-B cell-enhancing factor; pre-B-cell colony enhancing factor 1; Pre-B-cell colony-enhancing factor 1; VF; Visfatin

Gene Symbols: NAMPT

Molecular weight: 55,521 Da

Basal Isoelectric point: 6.69 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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PBEF

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