Arp3 ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Plays a role in ciliogenesis. Belongs to the actin family. ARP3 subfamily. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 2q14.1
Cellular Component:  actin cytoskeleton; Arp2/3 protein complex; brush border; cell-cell junction; cytoplasm; cytosol; lamellipodium; nucleus; site of double-strand break
Molecular Function:  actin filament binding; ATP binding; protein binding; structural constituent of cytoskeleton
Biological Process:  actin polymerization-dependent cell motility; Arp2/3 complex-mediated actin nucleation; asymmetric cell division; cellular response to type II interferon; cilium assembly; establishment or maintenance of cell polarity; meiotic chromosome movement towards spindle pole; meiotic cytokinesis; positive regulation of lamellipodium assembly; positive regulation of transcription by RNA polymerase II; spindle localization
Reference #:  P61158 (UniProtKB)
Alt. Names/Synonyms: actin related protein 3; Actin-like protein 3; Actin-related protein 3; ACTR3; ARP3; ARP3 actin related protein 3 homolog; ARP3 actin-related protein 3 homolog (yeast)
Gene Symbols: ACTR3
Molecular weight: 47,371 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene