SMYD3 Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Also methylates 'Lys-5' of histone H4. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Expressed in skeletal muscles and testis. Overexpressed in a majority of colorectal and hepatocellular carcinomas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Methyltransferase; Methyltransferase, protein lysine
Chromosomal Location of Human Ortholog: 1q44
Cellular Component:  cytosol; nucleoplasm; nucleus
Molecular Function:  histone-lysine N-methyltransferase activity; metal ion binding; protein binding; RNA polymerase II complex binding; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding
Biological Process:  cellular response to dexamethasone stimulus; establishment of protein localization; histone lysine methylation; myotube cell development; negative regulation of protein kinase activity; nucleosome assembly; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription by RNA polymerase II
Reference #:  Q9H7B4 (UniProtKB)
Alt. Names/Synonyms: bA74P14.1; bA74P14.1 (novel protein); FLJ21080; Histone-lysine N-methyltransferase SMYD3; KMT3E; MGC104324; SET and MYND domain containing 3; SET and MYND domain-containing protein 3; SMYD3; Zinc finger MYND domain-containing protein 1; zinc finger protein, subfamily 3A (MYND domain containing), 1; zinc finger, MYND domain containing 1; ZMYND1; ZNFN3A1
Gene Symbols: SMYD3
Molecular weight: 49,097 Da
Basal Isoelectric point: 7.05  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene