FAM48A Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy. Belongs to the SPT20 family. Highly expressed in testis, moderately in brain and pituitary gland. Expressed in several fetal tissues, including lung, brain, thymus and kidney. Expression is down-regulated in malignant prostate tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 3|3 C
Cellular Component:  SAGA complex
Molecular Function:  transcription coregulator activity
Biological Process:  gastrulation; multicellular organism development; positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter; regulation of transcription by RNA polymerase II
Reference #:  Q7TT00 (UniProtKB)
Alt. Names/Synonyms: AA667204; AI450544; D3Ertd300; D3Ertd300e; FA48A; Fam4; Fam48a; family with sequence similarity 48, member A; p38 interacting protein; p38-interacting protein; p38IP; Protein FAM48A; SP20H; SPT20 SAGA complex component; suppressor of Ty 20; Supt20; Supt20h; transcription factor (p38 interacting protein); Transcription factor SPT20 homolog
Gene Symbols: Fam48a
Molecular weight: 59,519 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene