FBL
S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus. Belongs to the methyltransferase superfamily. Fibrillarin family. Note: This description may include information from UniProtKB.
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Protein type: EC 2.1.1.-; Methyltransferase; Nucleolus; RNA processing; RNA-binding |
Chromosomal Location of rat Ortholog: 1q21 |
Cellular Component:
box C/D RNP complex; Cajal body; chromosome; dense fibrillar component; fibrillar center; granular component; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex; small-subunit processome
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Molecular Function:
ATPase binding; histone H2AQ104 methyltransferase activity; methyltransferase activity; protein binding; RNA binding; rRNA methyltransferase activity; TFIID-class transcription factor complex binding
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Biological Process:
box C/D RNA 3'-end processing; chromatin remodeling; methylation; ribosomal small subunit biogenesis; rRNA methylation; rRNA processing; sno(s)RNA metabolic process; snoRNA localization
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Reference #:
P22509
(UniProtKB)
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Alt. Names/Synonyms: Fbl; FBRL; fibrillarin; MGC116371; Nucleolar protein 1; rRNA 2'-O-methyltransferase fibrillarin
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Gene Symbols: Fbl
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Molecular weight:
34,222 Da
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Basal Isoelectric point:
10.25
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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