PSMB8 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Involved in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes. Belongs to the peptidase T1B family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: EC 3.4.25.1; Protease; Proteasome complex

Chromosomal Location of human Ortholog: 6p21.32

Cellular Component: cytosol; nucleoplasm; nucleus; proteasome complex; proteasome core complex; proteasome core complex, beta-subunit complex; spermatoproteasome complex

Molecular Function: endopeptidase activity; protein binding; threonine-type endopeptidase activity

Biological Process: antigen processing and presentation; fat cell differentiation; proteasomal protein catabolic process; regulation of endopeptidase activity

Disease: Autoinflammation, Lipodystrophy, And Dermatosis Syndrome

Reference #: P28062 (UniProtKB)

Alt. Names/Synonyms: ALDD; D6S216; D6S216E; JMP; LMP7; Low molecular mass protein 7; low molecular weight protein 7; Macropain subunit C13; MGC1491; Multicatalytic endopeptidase complex subunit C13; NKJO; PRAAS1; protease component C13; proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7); proteasome 20S subunit beta 8; proteasome catalytic subunit 3i; Proteasome component C13; proteasome subunit beta 5i; proteasome subunit beta 8; Proteasome subunit beta type-8; Proteasome subunit beta-5i; proteasome subunit Y2; proteasome-related gene 7; PSB8; PSMB5i; PSMB8; Really interesting new gene 10 protein; RING10; Y2

Gene Symbols: PSMB8

Molecular weight: 30,354 Da

Basal Isoelectric point: 7.04 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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PSMB8

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