PSMA3 Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. Belongs to the peptidase T1A family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.25.1; Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 14q23.1
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus; proteasome complex; proteasome core complex; proteasome core complex, alpha-subunit complex
Molecular Function:  protein binding; threonine-type endopeptidase activity; ubiquitin protein ligase binding
Biological Process:  anaphase-promoting complex-dependent catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; Fc-epsilon receptor signaling pathway; interleukin-1-mediated signaling pathway; MAPK cascade; negative regulation of canonical Wnt signaling pathway; negative regulation of G2/M transition of mitotic cell cycle; NIK/NF-kappaB signaling; positive regulation of canonical Wnt signaling pathway; post-translational protein modification; proteasome-mediated ubiquitin-dependent protein catabolic process; protein deubiquitination; protein polyubiquitination; regulation of cellular amino acid metabolic process; regulation of endopeptidase activity; regulation of hematopoietic stem cell differentiation; regulation of mitotic cell cycle phase transition; regulation of mRNA stability; regulation of transcription from RNA polymerase II promoter in response to hypoxia; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; transmembrane transport; tumor necrosis factor-mediated signaling pathway; viral process; Wnt signaling pathway, planar cell polarity pathway
Reference #:  P25788 (UniProtKB)
Alt. Names/Synonyms: HC8; Macropain subunit C8; MGC12306; MGC32631; Multicatalytic endopeptidase complex subunit C8; proteasome (prosome, macropain) subunit, alpha type, 3; proteasome 20S subunit alpha 3; Proteasome component C8; proteasome subunit alpha 3; Proteasome subunit alpha type-3; proteasome subunit alpha7; proteasome subunit C8; PSA3; PSC3; PSC8; PSMA3; testicular secretory protein Li 43
Gene Symbols: PSMA3
Molecular weight: 28,433 Da
Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PSMA3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein