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RACK1
a scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane. Promotes migration of breast carcinoma cells by binding to and activating RHOA. (Microbial infection) Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. (Microbial infection) Enhances phosphorylation of HIV-1 Nef by PKCs. (Microbial infection) In case of poxvirus infection, remodels the ribosomes so that they become optimal for the viral mRNAs (containing poly-A leaders) translation but not for host mRNAs. (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses. Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. In the liver, expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator |
| Chromosomal Location of human Ortholog: 5q35.3 |
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Cellular Component:
cytoplasm; cytosol; cytosolic small ribosomal subunit; dendrite; IRE1-RACK1-PP2A complex; midbody; mitochondrion; neuronal cell body; nucleoplasm; nucleus; perikaryon; perinuclear region of cytoplasm; phagocytic cup; small ribosomal subunit
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Molecular Function:
BH3 domain binding; cyclin binding; cysteine-type endopeptidase activator activity involved in apoptotic process; enzyme binding; ion channel inhibitor activity; molecular adaptor activity; protein binding; protein homodimerization activity; protein kinase C binding; protein phosphatase binding; protein tyrosine kinase inhibitor activity; receptor tyrosine kinase binding; ribosome binding; SH2 domain binding; signaling adaptor activity; signaling receptor binding; translation regulator activity
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Biological Process:
activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; cell cycle; cellular response to glucose stimulus; cellular response to growth factor stimulus; cytoplasmic translation; gastrulation; negative regulation of cell growth; negative regulation of endoplasmic reticulum unfolded protein response; negative regulation of gene expression; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide; negative regulation of peptidyl-serine phosphorylation; negative regulation of phagocytosis; negative regulation of protein binding; negative regulation of protein kinase B signaling; negative regulation of smoothened signaling pathway; negative regulation of translation; negative regulation of Wnt signaling pathway; pigmentation; positive regulation of apoptotic process; positive regulation of cell migration; positive regulation of cyclic-nucleotide phosphodiesterase activity; positive regulation of gastrulation; positive regulation of Golgi to plasma membrane protein transport; positive regulation of GTPase activity; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of mitochondrial depolarization; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein phosphorylation; positive regulation of protein-containing complex assembly; protein ubiquitination; regulation of cell cycle; regulation of cell division; regulation of establishment of cell polarity; regulation of protein localization; rescue of stalled ribosome; rhythmic process
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Reference #:
P63244
(UniProtKB)
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Alt. Names/Synonyms: Cell proliferation-inducing gene 21 protein; GBLP; Gnb2-rs1; GNB2L1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; guanine nucleotide binding protein beta polypeptide 2-like 1; Guanine nucleotide-binding protein subunit beta-2-like 1; Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed; Guanine nucleotide-binding protein subunit beta-like protein 12.3; H12.3; HLC-7; Human lung cancer oncogene 7 protein; lung cancer oncogene 7; PIG21; proliferation-inducing gene 21; protein homologous to chicken B complex protein, guanine nucleotide binding; RACK1; Receptor for activated C kinase; Receptor for Activated C Kinase 1; Receptor of activated protein C kinase 1; Receptor of activated protein C kinase 1, N-terminally processed; Receptor of activated protein kinase C 1; Small ribosomal subunit protein RACK1
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Gene Symbols: RACK1
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Molecular weight:
35,077 Da
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Basal Isoelectric point:
7.6
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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Growth And Differentiation Control by MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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