RPL8 a ribosomal protein of the L2P family. Located in the cytoplasm. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This protein is a component of the 60S subunit. Associates with 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Ribosomal; Translation
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component:  cytosol; cytosolic large ribosomal subunit; polysomal ribosome; postsynapse; postsynaptic density
Molecular Function:  5.8S rRNA binding; structural constituent of ribosome
Biological Process:  cellular response to nerve growth factor stimulus; cytoplasmic translation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; SRP-dependent cotranslational protein targeting to membrane; translation; translational initiation; viral transcription
Reference #:  P62917 (UniProtKB)
Alt. Names/Synonyms: 60S ribosomal protein L8; ribosomal protein L8; RL8; RPL8
Gene Symbols: RPL8
Molecular weight: 28,025 Da
Basal Isoelectric point: 11.04  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein