ERC1 iso2 Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. Widely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 12p13.33
Cellular Component:  centrosome; ciliary basal body; cytoplasm; Golgi membrane; IkappaB kinase complex; presynaptic membrane; synapse
Molecular Function:  leucine zipper domain binding; PDZ domain binding; protein binding; Rab GTPase binding
Biological Process:  I-kappaB phosphorylation; multicellular organism development; negative regulation of apoptotic process; positive regulation of NF-kappaB transcription factor activity; protein transport; regulation of transcription, DNA-templated; retrograde transport, endosome to Golgi
Reference #:  Q8IUD2-2 (UniProtKB)
Alt. Names/Synonyms: Cast2; ELKS; ELKS/Rab6-interacting/CAST family member 1; ERC-1; ERC1; ERC1 iso2; KIAA1081; RAB6 interacting protein 2; Rab6-interacting protein 2; RAB6IP2; RB6I2
Gene Symbols: ERC1
Molecular weight: 113,920 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling
Select Structure to View Below

ERC1 iso2

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein