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ERC1 iso2
Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. Widely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of Human Ortholog: 12p13.33 |
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Cellular Component:
centrosome; ciliary basal body; cytoplasm; Golgi membrane; IkappaB kinase complex; presynaptic membrane; synapse
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Molecular Function:
leucine zipper domain binding; PDZ domain binding; protein binding; Rab GTPase binding
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Biological Process:
I-kappaB phosphorylation; multicellular organism development; negative regulation of apoptotic process; positive regulation of NF-kappaB transcription factor activity; protein transport; regulation of transcription, DNA-templated; retrograde transport, endosome to Golgi
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Reference #:
Q8IUD2-2
(UniProtKB)
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Alt. Names/Synonyms: Cast2; ELKS; ELKS/Rab6-interacting/CAST family member 1; ERC-1; ERC1; ERC1 iso2; KIAA1081; RAB6 interacting protein 2; Rab6-interacting protein 2; RAB6IP2; RB6I2
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Gene Symbols: ERC1
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Molecular weight:
113,920 Da
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Basal Isoelectric point:
5.98
Predict pI for various phosphorylation states
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CST Pathways:
NF-kB Signaling
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