GART In the C-terminal section; belongs to the GART family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - one carbon pool by folate; EC; EC; EC; Ligase; Methyltransferase; Mitochondrial; Nucleotide Metabolism - purine
Chromosomal Location of human Ortholog: 21q22.11
Cellular Component:  cytosol
Molecular Function:  ATP binding; metal ion binding; phosphoribosylamine-glycine ligase activity; phosphoribosylformylglycinamidine cyclo-ligase activity; phosphoribosylglycinamide formyltransferase activity
Biological Process:  'de novo' AMP biosynthetic process; 'de novo' IMP biosynthetic process; 'de novo' XMP biosynthetic process; adenine biosynthetic process; brainstem development; cerebellum development; cerebral cortex development; glycine metabolic process; GMP biosynthetic process; purine nucleotide biosynthetic process; purine ribonucleoside monophosphate biosynthetic process; response to inorganic substance; response to organic substance; tetrahydrofolate biosynthetic process
Reference #:  P22102 (UniProtKB)
Alt. Names/Synonyms: 5'-phosphoribosylglycinamide transformylase; AIR synthase; AIRS; GAR transformylase; GARS; GARS-AIRS-GART; GART; GARTF; glycinamide ribonucleotide formyltransferase; Glycinamide ribonucleotide synthetase; glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase; MGC47764; PAIS; PGFT; Phosphoribosyl-aminoimidazole synthetase; Phosphoribosylamine--glycine ligase; Phosphoribosylformylglycinamidine cyclo-ligase; Phosphoribosylglycinamide formyltransferase; phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; Phosphoribosylglycinamide synthetase; PRGS; PUR2; Trifunctional purine biosynthetic protein adenosine-3
Gene Symbols: GART
Molecular weight: 107,767 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein