GART In the C-terminal section; belongs to the GART family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.2.2; EC 6.3.3.1; EC 6.3.4.13; Ligase; Methyltransferase; Mitochondrial; Nucleotide Metabolism - purine
Chromosomal Location of Human Ortholog: 21q22.11
Cellular Component:  cytosol
Molecular Function:  ATP binding; metal ion binding; phosphoribosylamine-glycine ligase activity; phosphoribosylformylglycinamidine cyclo-ligase activity; phosphoribosylglycinamide formyltransferase activity
Biological Process:  'de novo' IMP biosynthetic process; brainstem development; cerebellum development; cerebral cortex development; glycine metabolic process; purine ribonucleoside monophosphate biosynthetic process; response to inorganic substance; response to organic substance; tetrahydrofolate biosynthetic process
Reference #:  P22102 (UniProtKB)
Alt. Names/Synonyms: 5'-phosphoribosylglycinamide transformylase; AIR synthase; AIRS; GAR transformylase; GARS; GART; GARTF; Glycinamide ribonucleotide synthetase; MGC47764; PAIS; PGFT; Phosphoribosyl-aminoimidazole synthetase; Phosphoribosylamine--glycine ligase; Phosphoribosylformylglycinamidine cyclo-ligase; Phosphoribosylglycinamide formyltransferase; phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; Phosphoribosylglycinamide synthetase; PRGS; PUR2; Trifunctional purine biosynthetic protein adenosine-3
Gene Symbols: GART
Molecular weight: 107,767 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
Select Structure to View Below

GART

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein