tensin 2 iso2 Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling. Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Cell cycle regulation; EC 3.1.3.-; Phosphatase
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component:  focal adhesion; plasma membrane
Molecular Function:  kinase binding; metal ion binding; phosphoprotein phosphatase activity; protein binding
Biological Process:  cellular homeostasis; collagen metabolic process; intracellular signal transduction; kidney development; multicellular organism growth; multicellular organismal homeostasis; negative regulation of cell proliferation; protein dephosphorylation; response to muscle activity
Reference #:  Q63HR2-2 (UniProtKB)
Alt. Names/Synonyms: C1 domain-containing phosphatase and tensin homolog; C1-TEN; KIAA1075; TENC1; Tensin-2; Tensin-like C1 domain-containing phosphatase; TNS2
Gene Symbols: TNS2
Molecular weight: 142,685 Da
Basal Isoelectric point: 8.63  Predict pI for various phosphorylation states
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tensin 2 iso2

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein