TGM2 Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Belongs to the transglutaminase superfamily. Transglutaminase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.3.2.13; Transferase
Chromosomal Location of human Ortholog: 20q11.23
Cellular Component:  chromatin; cytosol; endoplasmic reticulum; extracellular matrix; mitochondrion; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  calcium ion binding; GTP binding; histone dopaminyltransferase activity; histone serotonyltransferase activity; peptidase activity; peptide histaminyltransferase activity; peptide noradrenalinyltransferase activity; protein binding; protein-glutamine gamma-glutamyltransferase activity; protein-glutamine glutaminase activity
Biological Process:  apoptotic cell clearance; bone development; branching involved in salivary gland morphogenesis; cellular response to cocaine; cellular response to dopamine; cellular response to serotonin; histone modification; negative regulation of endoplasmic reticulum calcium ion concentration; peptide cross-linking; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of apoptotic process; positive regulation of cell adhesion; positive regulation of GTPase activity; positive regulation of mitochondrial calcium ion concentration; positive regulation of neurogenesis; positive regulation of small GTPase mediated signal transduction; protein deamination; proteolysis; regulation of apoptotic cell clearance; regulation of apoptotic process; salivary gland cavitation
Reference #:  P21980 (UniProtKB)
Alt. Names/Synonyms: C polypeptide; C polypeptide, protein-glutamine-gamma-glutamyltransferase; G-ALPHA-h; GNAH; Protein-glutamine gamma-glutamyltransferase 2; protein-glutamine-gamma-glutamyltransferase; TG(C); TG2; TGase C; TGase H; TGase-2; TGase-H; TGC; TGM2; Tissue transglutaminase; transglutaminase 2; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); Transglutaminase C; Transglutaminase H; Transglutaminase-2
Gene Symbols: TGM2
Molecular weight: 77,329 Da
Basal Isoelectric point: 5.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TGM2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein