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TGM2
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Belongs to the transglutaminase superfamily. Transglutaminase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.3.2.13; Transferase |
| Chromosomal Location of Human Ortholog: 20q11.23 |
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Cellular Component:
cytosol; endoplasmic reticulum; intrinsic component of plasma membrane; mitochondrion
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Molecular Function:
GTP binding; metal ion binding; protein binding; protein domain specific binding; protein-glutamine gamma-glutamyltransferase activity
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Biological Process:
apoptotic cell clearance; blood vessel remodeling; branching involved in salivary gland morphogenesis; isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; negative regulation of endoplasmic reticulum calcium ion concentration; positive regulation of apoptotic process; positive regulation of cell adhesion; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of inflammatory response; positive regulation of mitochondrial calcium ion concentration; positive regulation of smooth muscle cell proliferation; protein homooligomerization; salivary gland cavitation
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Reference #:
P21980
(UniProtKB)
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Alt. Names/Synonyms: C polypeptide; C polypeptide, protein-glutamine-gamma-glutamyltransferase; G-ALPHA-h; GNAH; Protein-glutamine gamma-glutamyltransferase 2; protein-glutamine-gamma-glutamyltransferase; TG(C); TG2; TGase C; TGase H; TGase-2; TGase-H; TGC; TGM2; Tissue transglutaminase; transglutaminase 2; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); Transglutaminase C; Transglutaminase H; Transglutaminase-2
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Gene Symbols: TGM2
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Molecular weight:
77,329 Da
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Basal Isoelectric point:
5.11
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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