|
CHD-4 iso2
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Belongs to the SNF2/RAD54 helicase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: DNA-binding; EC 3.6.4.12; Helicase |
| Chromosomal Location of human Ortholog: 12p13.31 |
|
Cellular Component:
centrosome; cerebellar granule cell to Purkinje cell synapse; chromatin; chromosome, telomeric region; cytoplasm; nucleoplasm; nucleus; NuRD complex; RNA polymerase II transcription regulator complex; site of DNA damage
|
|
Molecular Function:
ATP binding; ATP hydrolysis activity; ATP-dependent chromatin remodeler activity; chromatin binding; DNA binding; helicase activity; histone binding; histone deacetylase binding; protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription coregulator binding; transcription corepressor activity; zinc ion binding
|
|
Biological Process:
chromatin remodeling; double-strand break repair via homologous recombination; histone deacetylation; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; regulation of cell fate specification; regulation of stem cell differentiation; regulation of synapse assembly; terminal button organization
|
|
Reference #:
Q14839-2
(UniProtKB)
|
|
Alt. Names/Synonyms: ATP-dependent helicase CHD4; CHD-4; CHD-4 iso2; CHD4; chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4; Mi-2 autoantigen 218 kDa protein; Mi-2b; Mi2-beta; SIHIWES
|
|
Gene Symbols: CHD4
|
|
Molecular weight:
220,848 Da
|
|
Basal Isoelectric point:
5.7
Predict pI for various phosphorylation states
|
|
CST Pathways:
Protein Acetylation
|
