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MBLR iso3
Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Ubiquitin conjugating system |
| Chromosomal Location of human Ortholog: 10q24.33 |
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Cellular Component:
nucleoplasm; nucleus; PcG protein complex; PRC1 complex
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Molecular Function:
metal ion binding; protein binding
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Biological Process:
chromatin remodeling; histone H2A-K119 monoubiquitination; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II
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Reference #:
Q9BYE7-3
(UniProtKB)
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Alt. Names/Synonyms: MBLR; MBLR iso3; Mel18 and Bmi1-like RING finger; Mel18 and Bmi1-like RING finger protein; PCGF6; polycomb group ring finger 6; Polycomb group RING finger protein 6; RING finger protein 134; RNF134
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Gene Symbols: PCGF6
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Molecular weight:
30,249 Da
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Basal Isoelectric point:
4.69
Predict pI for various phosphorylation states
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