RIPK1 iso2 Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL
Chromosomal Location of Human Ortholog: 6p25.2
Cellular Component:  cytosol; death-inducing signaling complex; endosome membrane; membrane raft; mitochondrion; receptor complex; ripoptosome
Molecular Function:  ATP binding; death domain binding; death receptor binding; identical protein binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; ubiquitin protein ligase binding
Biological Process:  activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of JNKK activity; activation of JUN kinase activity; amyloid fibril formation; apoptotic process; apoptotic signaling pathway; cellular protein catabolic process; cellular response to growth factor stimulus; cellular response to hydrogen peroxide; cellular response to tumor necrosis factor; death-inducing signaling complex assembly; extrinsic apoptotic signaling pathway; I-kappaB kinase/NF-kappaB signaling; MyD88-independent toll-like receptor signaling pathway; necroptotic process; necroptotic signaling pathway; negative regulation of cardiac muscle cell proliferation; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of I-kappaB kinase/NF-kappaB signaling; peptidyl-serine autophosphorylation; positive regulation of apoptotic process; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of hydrogen peroxide-induced cell death; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-8 production; positive regulation of JNK cascade; positive regulation of macrophage differentiation; positive regulation of necroptotic process; positive regulation of necrotic cell death; positive regulation of NF-kappaB transcription factor activity; positive regulation of production of miRNAs involved in gene silencing by miRNA; positive regulation of programmed cell death; positive regulation of protein phosphorylation; positive regulation of reactive oxygen species metabolic process; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of tumor necrosis factor-mediated signaling pathway; programmed necrotic cell death; protein autophosphorylation; protein deubiquitination; protein heterooligomerization; protein homooligomerization; regulation of ATP:ADP antiporter activity; regulation of extrinsic apoptotic signaling pathway via death domain receptors; regulation of tumor necrosis factor-mediated signaling pathway; response to tumor necrosis factor; ripoptosome assembly; ripoptosome assembly involved in necroptotic process; T cell apoptotic process; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; viral process
Reference #:  Q13546-2 (UniProtKB)
Alt. Names/Synonyms: AIEFL; Cell death protein RIP; IMD57; receptor (TNFRSF)-interacting serine-threonine kinase 1; receptor interacting serine/threonine kinase 1; Receptor-interacting protein 1; receptor-interacting protein kinase 1; Receptor-interacting serine/threonine-protein kinase 1; RIP; RIP-1; RIP1; RIPK1; RIPK1 iso2; Serine/threonine-protein kinase RIP
Gene Symbols: RIPK1
Molecular weight: 70,733 Da
Basal Isoelectric point: 5.81  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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RIPK1 iso2

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene