RASA1 iso2 Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1. In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 5q14.3
Cellular Component:  cytoplasm; cytosol; plasma membrane; ruffle
Molecular Function:  GTPase activator activity; GTPase activity; GTPase binding; phosphotyrosine residue binding; potassium channel inhibitor activity; protein binding; signaling receptor binding
Biological Process:  blood vessel morphogenesis; ephrin receptor signaling pathway; intracellular signal transduction; MAPK cascade; mitotic cytokinesis; negative regulation of apoptotic process; negative regulation of cell adhesion; negative regulation of cell-matrix adhesion; negative regulation of neuron apoptotic process; negative regulation of Ras protein signal transduction; positive regulation of GTPase activity; regulation of actin filament polymerization; regulation of cell shape; regulation of RNA metabolic process; signal transduction; vasculogenesis
Reference #:  P20936-2 (UniProtKB)
Alt. Names/Synonyms: CM-AVM; CMAVM; CMAVM1; GAP; GTPase-activating protein; p120; p120 RAS GTPase activating protein; p120GAP; p120RASGAP; PKWS; Ras GTPase-activating protein 1; Ras p21 protein activator; RAS p21 protein activator (GTPase activating protein) 1; RAS p21 protein activator 1; RASA; RASA1; RASA1 iso2; RasGAP; triphosphatase-activating protein
Gene Symbols: RASA1
Molecular weight: 100,398 Da
Basal Isoelectric point: 7.36  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  T Cell Receptor Signaling
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RASA1 iso2

Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein